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Jan 5th, 2021

UltraPlex 1-Step ToughMix used in direct-lysis saliva SARS-CoV-2 detection  Download Protocol

Sep 9th, 2020

Quantabio launches qScript 1-Step Virus ToughMix - optimized to detect low copy inputs in Flu-A, Flu-B and SARS-CoV-2

Jul 16th, 2020

Quantabio’s UltraPlex 1-Step ToughMix Continues to Enhance CDC Protocols to Detect and Differentiate COVID-19 and Influenza Respiratory Diseases Read More

Apr 15th, 2020

CDC Adds Two Quantabio RT-qPCR ToughMix Kits to COVID-19 Diagnostic Testing Protocol Read More      Download CDC Protocol

2 CDC EUA Approved Products

Message from Quantabio


We are working tirelessly to increase our production capacities as it relates to the following RNA RT-qPCR reagents.

Cited in the CDC protocol that has received FDA Emergency Use Authorization (EUA) approval:

Reagents Manufactured for +56M Tests
COVID-19 Testing Solution Reagents Used in over 37 Countries COVID-19 testing solution reagents used in over 37 countries
+100 Partner Testing Companies
What Customers say
qScript 1-Step Virus ToughMix performed BETTER than other 3 mixes and amplified very well the S target from SARS-CoV-2 in a highly multiplex environment.
G. Casallo
Sick Kids - Molecular Diagnostics Lab

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Product Comparisons


Determine which RT-qPCR kit is right for your research needs

qScript XLT 1-Step
RT-qPCR ToughMix
qScript 1-Step Virus ToughMixUltraPlex 1-Step ToughMix
Recommended in
CDC protocol
Detection purified RNA
Extraction-free detection
Saliva-direct detection
Formulation 2X master mix 2X master mix 4X master mix
Taq Hot Start Yes Yes Yes
RT Hot Start No Yes Yes
Chemistry 1 tube SuperMix 1 tube SuperMix 1 tube SuperMix
Performance ++++ ++++ ++++
Cycling Conditions Fast or Standard qPCR Cycling Fast or Standard qPCR Cycling Fast or Standard qPCR Cycling
Multiplex Capabilty Up to 4 targets Up to 4 targets Up to 5 targets
Sensitivity +++ ++++ ++++
Inhibitor Tolerance Yes Yes Yes

What Customer's Say


qScript 1-Step Virus ToughMix performed BETTER than other 3 mixes and amplified very well the S target from SARS-CoV-2 in a highly multiplex environment.
G. Casallo
Sick Kids - Molecular Diagnostics Lab
Compared to other 1-step qRT-PCR mixes we have used, UltraPlex 1-Step ToughMix (4X) Low-ROX, 500R performs with the same sensitivity when testing using SARS-CoV-2-spiked saliva... Read More Compared to other 1-step qRT-PCR mixes we have used, UltraPlex 1-Step ToughMix (4X) Low-ROX, 500R performs with the same sensitivity when testing using SARS-CoV-2-spiked saliva samples, but is easier to use and at a significantly lower price per reaction. The mix requires little to no time to thaw, decreasing the time required when preparing samples. The mix is also conveniently aliquoted into multiple tubes, reducing the chance for contamination as opposed to a single, high volume aliquot. Overall, these factors make this a better overall product as compared to competing companies (e.g., Thermo Fisher Scientific or Zymo) and we will continue to use this moving forward.
Rhoel R. D., PhD, MPH
Professor of Infectious Diseases UF Eminent Scholar
Director CDC Southeastern Regional Center of Excellence for Vector Borne Diseases
We used the qScript XLT 1-step RT-qPCR ToughMix to reliably and very quickly identify an experimental drug candidate and demonstrate its efficacy to correct the debilitating effect of an inherited disease. The immediate success and impeccable performance of this mix shortened our labs time to result and confirmation easily by 2-3 months.
Lead Scientist
Researcher TransLab, Children’s Hospital Boston

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